人物经历

1992年本科毕业于山东大学生化专业，1999年华东师范大学生理学硕士毕业，2002年中国科学院上海药物研究所药理学博士毕业。2002年7月至2009年9月先后在美国德克萨斯大学圣安东尼奥医学中心和达拉斯西南医学中心从事研究工作。2009年9月入选中国科学院百人计划，在上海药物研究所担任课题组长。

研究方向

离子通道和受体是重要的膜蛋白，不仅发挥重要的生理功能，也是主要的药物作用靶点。我们综合电生理学、药理学和结构生物学等技术手段，研究受体与离子通道的调控机制，开展钾通道的结构与功能研究。最近针对抑郁症等神经系统疾病，我们进一步开展了动物行为学和在体电生理学研究，从天然产物中筛选和发现新的抗抑郁药物；同时“以药效测机制”开展药理学机制研究。

主要贡献

代表论著：

Zhang X, Wang J, Feng Y, Ge J, Li W, Sun W, Iscla I, Yu J, Blount P, Li Y*, Yang M*. Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance. Proc Natl Acad Sci U S A.

Ning Shia,1, Weizong Zenga,1, Sheng Yeb, Yang Lic* and Youxing Jianga*. Crucial Points within the Pore as Determinants of K+ Channel Conductance and Gating，JOURNAL OF MOLECULAR BIOLOGY.

Derebe MG, Zeng W, Li Y, Alam A, Jiang Y. Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore.

Sheng Ye1, Yang Li2 & Youxing Jiang3,4 Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore. Nature structural & molecular biology.

Li Y, Berke I, Chen L, Jiang Y. Gating and inward rectifying properties of the MthK K+ channel with and without the gaing ring. J. Gen. Physiol.

Ye S, Li Y, Chen L, Jiang Y. Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K+ Channels. Cell.

Gamper N, Zaika O, Li Y, Martin P, Hernandez CC, Perez MR, Wang AY, Jaffe DB, Shapiro MS. Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing. EMBO J.

Li Y, Gamper N, Hilgemann DW, Shapiro MS. Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate.J. Neurosci.

Gamper N, Li Y, Shapiro MS. Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin. Mol Biol Cell.

Li Y, Langlais P, Gamper N, Liu F, Shapiro MS. Dual phosphorylations underlie modulation of unitary KCNQ K+ channels by Src tyrosine kinase. J. Biol.

Li Y, Gamper N, Shapiro MS. Single-channel analysis of KCNQ K+ channels reveals the mechanism of augmentation by a cysteine-modifying reagent. J. Neurosci.

Liu, H.; Li, Y.; Song, M.; Tan, X.; Cheng, F.; Zheng, S.; Shen, J.; Luo, X.; Ji, R.; Yue, J.; Hu, G.; Jiang, H.; Chen, K. Structure-based discovery of potassium channel blockers from natural products: virtual screening and electrophysiological assay testing. Chem. Biol.

Liu H, Gao ZB, Yao Z, Zheng S, Li Y, Zhu W, Tan X, Luo X, Shen J, Chen K, Hu GY, Jiang H. Discovering potassium channel blockers from synthetic compound database by using structure-based virtual screening in conjunction with electrophysiological assay.