人物经历

癌基因及相关基因国家重点实验室研究员，系统生物医学教育部重点实验室常务副主任，科技部重大科学研究计划（973）项目首席科学家，国务院政府特殊津贴专家，上海市浦江学者，中美生命科学家学会终身会员，神经科学学会会员。1990年和1993年分别获得复旦大学学士和硕士。1998年获美国纽约州立大学石溪分校细胞发育生物学博士。1999年-2001年，哈佛大学博士后，Damon Runyon Research Fellow。2008年回国前任犹他大学助理教授。

获得Stony Brook University Excellent Research Award，The Second Annual RNA Society Prize，American Cancer Society Research Scholar Award，Basil O’Connor Scholar Award等奖项。研究论文发表于Science，RNA，MCB，Cell，PNAS，Molecular Cell，Genetics，Neuroscience，Genome Research，Nature Genetics，Nature Protocol和JMCB等期刊上，并申请了国家专利。现任ABBS编委，并为多种国际知名期刊审稿，以及科技部重大科学研究计划，国家自然科学基金，教育部优秀博士论文和博士点基金，上海市科委重大项目等评审。

长期研究神经系统、药物代谢系统和肿瘤基因家族的表达调控和在体功能。用比较生物医学手段，开发分子遗传学新技术新方法，研究原钙粘蛋白家族在脑发育和脑功能中的细胞分子机制及UGT家族在药物代谢中的生理功能和表达调控原理,以小鼠为模式动物研究人类重要常见复杂神经精神疾病的发生发展机理,为其最终治疗提供理论基础

代表论著

Huang H. and Wu, Q*. (2010). Cloning and comparative analyses of the zebrafish Ugt repertoire reveal its evolutionary diversity. PLoS ONE 5: E9144.

Ying,G., Wu, S., Hou, R., Huang, W., Capecchi, M., Wu, Q*. (2009). Protocadherin Celsr3 is required for interneuron migration in the mouse forebrain. Molecular and Cellular Biology 29:3045-3061.

Wu, S., Ying, G., Wu, Q., and Capecchi, M.R. (2008). A protocol for constructing gene targeting vectors: generating knockout mice for the cadherin family and beyond. Nature Protocol 3:1056-1076.

Zou, C., Huang, W., Ying, G., and Wu, Q*. (2007). Sequence analysis and expression mapping of the rat clustered protocadherin gene repertoires. Neuroscience 144: 579-603.

Wu, S., Ying, G., Wu, Q., and Capecchi, M.R. (2007). Towards simpler and faster genome-wide mutagenesis in mice. Nature Genetics 39: 922-930.

Li, C. and Wu, Q*. (2007). Evolution of vertebrate multiple variable first exons and structural diversity of drug metabolizing enzymes. BMC Evolutionary Biology 7: 69.

Wu, Q*#. (2005). Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes. Genetics 169:2179-2188.

Zhang, T., Haws, P., and Wu, Q*. (2004) Multiple variable first exons: a mechanism for cell- and tissue- specific gene regulation. Genome Research 14: 70-89.

Tasic, B., Nabholz, C.E., Baldwin, K.K., Kim, Y., Rueckert, E.H., Ribich, S.A., Cramer, P., Wu, Q., Axel, R., and Maniatis T. (2002). Promoter choice determines splice site selection in protocadherin  and  pre-mRNA splicing. Mol. Cell 10: 21-33.

Wu, Q#., Zhang, T., Cheng, J.-F., Kim, Y., Grimwood, J., Schmutz, J., Dickson, M., Noonan, J.P., Zhang, M.Q., Myers, R.M., and Maniatis, T. (2001). Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Research 11: 389-404.

Wu, Q#. and Maniatis, T. (2000). Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. Proc Natl Acad Sci USA 97:3124-3129.

Pohl U., Smith J.S., Tachibana I., Ueki K., Lee H.K., Ramaswamy S., Wu Q., Mohrenweiser H.W., Jenkins R.B., Louis D.N. (2000). EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins. Genomics 63: 255-262.

Wu, Q#. and Maniatis, T. (1999) A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell 97: 779-790.

Wu, Q#. and Krainer, A.R. (1999) AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes. Molecular and Cellular Biology 19: 3225-3236.