人物生平

1992-1996 清华大学生物科学与技术系，学士

1996-2001 清华大学生物科学与技术系，博士

2001-2006 美国劳伦斯伯克利国家实验室生命科学部，博士后

2006-2008 美国劳伦斯伯克利国家实验室生命科学部，研究科学家

2009-2011 美国耶鲁大学分子生物物理与生物化学系，Tenure-Track助理教授

2010.12-至今 清华大学生命科学学院，教授、博导

主要成就

王宏伟教授长期致力于使用冷冻电镜技术研究生物大分子的结构以及其组装机制，研究领域集中在细胞骨架动态机理、RNA降解、RNA干扰以及冷冻电镜方法学。目前已获得微管和Exosome等的高分辨电镜结构。此外，王宏伟教授还与其他课题组合作，解析了一批具有重要生物学意义的生物大分子的结构。

出版著作

1. Chang S, Sun D, Liang H, Wang J, Li J, Guo L, Wang X, Guan C, Boruah BM, Yuan L, Feng F, Yang M, Wang L, Wang Y, Wojdyla J, Li L, Wang J, Wang M, Cheng G,Wang HW*, and Liu Y*. (2015) Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 Å Resolution.Mol. Cell,57, 925-935. (*co-corresponding authors)

2. Liu JJ, Bratkowski MA, Liu X, Niu CY, Ke A*, andWang HW*. (2014) Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM.Nat. Struct. Mol. Biol.,21, 95-102. (*co-corresponding authors)

3. Li Y, Hsin J, Zhao L, Cheng Y, Shang W, Huang KC,Wang HW, and Ye S. (2013) FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation.Science,341: 392-295.

4. Taylor DW, Ma E, Shigematsu H, Cianfrocco MA, Noland CL, Nagayama K, Nogales E, Doudna JA*, andWang HW*. (2013) Substrate-specific structural rearrangements of human Dicer.Nat. Struct. Mol. Biol.,20, 662-670. (*co-corresponding authors)

5. Chen X, Taylor DW, Fowler CC, Galan JE,Wang HW, and Wolin SL. (2013) An RNA degradation machine sculpted by Ro autoantigen and noncoding RNA.Cell,153: 166-177.

6. Shen QT, Hsiue PP, Sindelar CV, Welch MD, Campellone KG*, andWang HW*. (2012) Structural insight into WHAMM-mediated cytoskeletal coordination during membrane remodeling.J. Cell Biol.,199, 111-124. (*co-corresponding authors)

7. Zhou K, Kanai R, Lee P,Wang HW*, and Modis Y*. (2012) Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin.J. Struct. Biol.,177: 402-409 (*co-corresponding authors)

8. Liu XQ andWang HW. (2011) Single particle electron microscopy reconstruction of the exosome complex using the random conical tilt method.J. Vis. Exp.,doi: 10.3791/2574.

9. Wu X, Shen QT, Stokes N, Lu C, Zheng Q, Polak L,Wang HWand Fuchs E. (2011) Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β.Cell,144, 341-352.