人物经历

学习经历

1991/09 - 1994/07，华南理工大学，发酵工程，博士

1988/09 - 1991/07，华南理工大学，发酵工程，硕士

1984/09 - 1988/07，华南理工大学，生物化工，学士1

工作经历

1994/07 -至今，暨南大学，生命科学技术学院，历任讲师、副教授、教授

1995/10 - 1996/10，日本大阪大学，生物工学国际交流中心，访问学者

2003/08 - 2005/08，美国加州大学伯克利分校，公共卫生学院，访问学者1

研究方向

1）病毒分子生物学；

2）基因沉默技术和抗病毒技术；

3）基因工程药物的研究与开发。如 糖尿病药物GLP-1衍生物研发等；

4）蛋白质工程为基础的分子改造，如进化的方式改善蛋白质功能等。1

学术成果

主要论文

代表性研究成果1

1.Feng L, Sheng J, Vu GP, Liu Y, Foo C, Wu S, Trang P, Paliza-Carre M, Ran Y, Yang X, Sun X, Deng Z, Zhou T, Lu S,Li H（通讯作者）,Liu F.Human cytomegalovirus UL23 inhibits transcription of interferon-γ stimulated genes and blocks antiviral interferon-γ responses by interacting with human N-myc interactor protein.PLoS Pathog.2018 Jan 29;14(1):e1006867. doi: 10.1371 2018 Jan

1. 1.

   Liu MY,Liu J,Lai W,Luo J,Liu Y,Vu GP,Yang Z,Trang P,Li H（通讯作者）,Wu J. Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012.Sci Rep.2016 Dec 12;6:38451. doi: 10.1038/srep38451

2. 2.

   Liu H, Wang X, Liu S,Li H, Yuan X, Feng B, Bai H, Zhao B,Chu Y,Li H.Effects and mechanism of miR-23b on glucose-mediated epithelial-to-mesenchymal transition in diabetic nephropathy.Int J Biochem Cell Biol.2016 Jan;70:149-60

3. 3.

   Li H（通讯作者）,Ma Y, Chen Y, Sang Y, Zhou T, Qiu M, Huang X, Zhou C, Su Z.A protease-based strategy for the controlled release of therapeutic peptides.Angew Chem Int Ed Engl.2010 Jul 5;49(29):4930-3

4. 4.

   Li H, Zhou CX, Su Z .Protease-resistant glucagon like peptide-1 analogs with long-term anti-diabetes type 2 activity.Adv Exp Med Biol. 2009;611:475-6.

5. 5.

   Li HLi Y, Ni F, Su ZInhibition of pathogenically-related morphologic transition in Candida albicans by disrupting Cdc42 binding to its effectors.Adv Exp Med Biol.2009;611:471-2.

6. 6.

   Li H,Zhou CX,Su JZChemical ligation and cleavage on solid support facilitate recombinant peptide purification.Protein Expr Purif.2006 Dec;50(2):238-46. Epub 2006 Sep 12.

7. 7.

   Li H,Trang P,Kim K,Zhou T,Umamoto S,Liu F.Effective inhibition of human cytomegalovirus gene expression and growth by intracellular expression of external Q1 guide sequence2006RNAVol.12 No.1 63-72

8. 8.

   Wang K, Li Y, Zhao G, Wu Y, Zhang X,Li H,Zhou T.Inhibition of human cytomegalovirus DNA replication by small interfering RNAs targeted to UL49.ActaBiochim Biophys Sin (Shanghai). 2013 May;45(5):401-7

9. 9.

   .Bai Y, Gong H,Li H, Vu GP, Lu S, Liu F.Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice.Proc Natl Acad Sci U S A. 2011 Feb 7 22;108(8):3222-7

10. 10.

    Bai Y,Li H, Vu GP, Gong H, Umamoto S, Zhou T, Lu S, Liu F.Salmonella-mediated delivery of RNase P-based ribozymes for inhibition of viral gene expression and replication in human cells.Proc Natl Acad Sci U S A.2010 Apr 20;107(16):7269-74

11. 11.

    Zhang W,Li H,Li Y, Zeng Z, Li S, Zhang X, Zou Y, Zhou T.Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P.Virol J.2010 May 18;7:100

12. 12.

    Zeng Z,Li H, Li Y, Cui Y, Zhou Q, Zou Y, Yang G, Zhou T.Effective inhibition of human cytomegalovirus gene expression by DNA-based external guide sequences.Acta Biochim Biophys Sin (Shanghai). 2009 May;41(5):389-98

13. 13.

    Zhou T, Xiao X, Xu B,Li H, Zou Y.Overexpression of SSTR2 inhibited the growth of SSTR2-positive tumors via multiple signaling pathways.Acta Oncol.2009;48(3):401-10.

14. 14.

    Bai Y,Trang P,Li H,Kim K,Zhou T,Liu F.Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNA.Proc Natl Acad Sci U S A.2008 Aug 5;105(31) :10919-24.

15. 15.

    Su ZD,Li HJ, Li Y and Ni F, Inhibition of pathogenically-related morphological transition inCandida albicansthrough intervening interactions of Cdc42 with its effectors: Impact on signal transduction therapy ,Chemistry & Biology(Cell Press),2007，Nov.14(11):1273-82

16. 16.

    Guo F, Huang X, Li S, Sun L, Li Y,Li H, Zhou Y, Chu Y, Zhou T.Identification of prosaposin as a novel interaction partner for Rhox5.J Genet Genomics. 2007 May;34(5):392-9

17. 17.

    Yang YH,Li H,Zhou T,Kim K,Liu FEngineered external guide sequences are highly effective in inducing RNase P for inhibition of gene expression and replication of human cytomegalovirusNucleic Acids Research,2006, Vol. 34, No.2575-583

18. 18.

    Zhang WJ,Li HJ,Li YQ,He HK,Tang DS,Zhang X,Zhou TH.Construction of An Effective M1GS Ribozyme Targeting HCMV UL97 mRNA Segmentin Vitro.Acta Genetica Sinica, November 2005,32(11),1205-1212

19. 19.

    Su YZ,Li HJ,Li YQ,Chen HJ,Tang DS,Zhang X,Jiang H,Zhou TH. In Vitro Construction of Effective M1GS Ribozymes Targeting HCMV UL54 RNA Segments.Acta Biochimica et Biophysica Sinica, 2005, 37(3):210-211