基本内容

教育经历1988－1991 卫生部兰州生物制品研究所 医学硕士1997－2001 武汉大学 理学博士2003－2005 美国加州大学(UCI) 博士后

研究领域抗病毒免疫和病毒基因工程疫苗；病毒基因组复制及其调控获资助项目国家973、国家863计划、国家自然科学基金、回国留学人员基金、湖北省和武汉市科技攻关等。

近期代表性论文1. Mengcheng Luo, Xiao Qu, Ruangang Pan, Dandan Zhu, Yuan Zhang, Jianguo Wu, Zishu Pan*. (2011). The virus-induced signaling adaptor molecule enhances DNA-raised immune protection against H5N1 influenza virus infection in mice. Vaccine 29, 2561-2567.

2. Chao Wan, Li Yi, Zhenhua Yang, Jun Yang, Huabin Shao, Chuyu Zhang, Zishu Pan*. (2010). The Toll-like receptor adaptor molecule TRIF enhances DNA vaccination against classical swine fever. Veterinary Immunology and Immunopathology 137, 47–53. 3. Xiufen Zou, Xueshuang Xiang, Yan Chen, Tao Peng, Xuelian Luo, Zishu Pan*. (2010). Understanding inhibition of viral proteins on type I IFN signaling pathways with modeling and optimization. Journal of Theoretical Biology 265, 691–703.

4. Pan Tao, Mengcheng Luo, Ruangang Pan, Dawei Ling, Siyu Zhou, Po Tien, Zishu Pan*. (2009). Enhanced protective immunity against H5N1 influenza virus challenge by vaccination with DNA expressing a chimeric hemagglutinin in combination with an MHC class I-restricted epitope of nucleoprotein in mice. Antiviral Research 81, 253-260.

5. Xuelian Luo, Ruangang Pan, Chao Wan, Xinfeng Liu, Jianguo Wu, Zishu Pan*. (2009). Glycosylation of classical swine fever virus E(rns) is essential for binding double-stranded RNA and preventing interferon-beta induction. Virus Research 146,135-139.

6. Guoyuan Wen, Jinnuo Xue, Yanping Shen, Chuyu Zhang, Zishu Pan*. (2009). Characterization of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) helicase activity and its modulation by CSFV RNA-dependent RNA polymerase. Virus Research 141, 63-70.

7. Pan Tao, Mengcheng Luo, Dandan Zhu, Sanfu Qu, Zhenhua Yang, Meng Gao, Deyin Guo, Zishu Pan*. (2009).Virus-like particle vaccine comprised of the HA, NA, and M1 proteins of an avian isolated H5N1 influenza virus induces protective immunity against homologous and heterologous strains in mice. Viral Immunology 22,273-281.

8. Pan Tao, Li Dai, Mengcheng Luo, Fangqiang Tang, Po Tien, Zishu Pan*. (2009). Analysis of synonymous codon usage in classicalswine fever virus. Virus Genes 38, 104-12.

9. Mengcheng Luo, Pan Tao, Junwei Li, Siyu Zhou, Deyin Guo, Zishu Pan*. (2008). Immunization with plasmid DNA encoding influenza A virus nucleoprotein fused to a tissue plasminogen activator signal sequence elicits strong immune responses and protection against H5N1 challenge in mice. Journal of Virological Methods 154,121–127.

10. Zou X, Peng T, Pan Z*. (2008). Modeling specificity in the yeast MAPK signaling networks. Journal of Theoretical Biology 250,139-155.

11. Yi Wang, Qin Wang, Xiaolu Lu, Chuyu Zhang, Xuezheng Fan, Zishu Pan, et al., (2008). 12-nt insertion in 3’ untranslated region leads to attenuation of classic swine fever virus and protects host against lethal challenge. Virology 374,390-398.

12. Pan Z, Sikandar S, Witherspoon M, Dizon D, Lipkin SM et al., (2008). Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) Mice. Developmental Dynamics 237,316-327.