研究方向

Biostatistics:Statistical Omics, Quantitative Genetics, High-throughput Big Data Analysis, Bioinformatics

人物经历

2007 年本科毕业于中国人民大学统计学院，2012 年于瑞典乌普萨拉大学(Uppsala University)获得生物信息学博士学位，主要贡献于数量遗传学的统计学方法创新研究与基因组大数据分析。在入职中山大学生命科学学院前，曾任英国爱丁堡大学 (University of Edinburgh) 和瑞典卡罗琳斯卡医学院 (Karolinska Institutet) 两所世界知名院校助理教授兼博士生导师。研究成果发表于Nature Genetics、Nature Communications、AmericanJournal of Human Genetics、PLoS Genetics等国际知名期刊，受到生物统计与统计遗传学领域的高度认可，曾在海外主持并获得了多项有国际竞争力的科研经费支持。在中山大学生命科学学院继续开展广泛的国际国内交叉学科合作，致力于从多种生物组学大数据分析中挖掘出新颖且具有高影响力的研究成果。

论文专著

Book

• Shen H, Yan Q,Shen X(沈恒范, 严钦容,沈侠) (2017): Probability and Mathematical Statistics (6th Edition Textbook) (概率论与数理统计教程 第六版, “十二五”普通高等教育本科国家级规划教材).Higher Education Press (高等教育出版社). ISBN 978-7-04-048049-8. [R Solutions for Examples (例题的R解答)]

Papers

Google Scholar

2018

• Nowak C, Hetty S, Salihovic S, Castillejo-Lopez C, Ganna A, Cook N, Broeckling CD, Prenni J,Shen X, Giedraitis V, Ärnlöv J, Lind L, Berne C, Sundström J, Fall T, Ingelsson E (2018): Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance.Scientific Reports, in press.

• Li X, Meng X, Spiliopoulou A, Timofeeva M, Wei W-Q, Gifford A,Shen X, He Y, Varley T, Tzoulaki I, Wright AF, Denny JC, Campbell H, Theodoratou E (2018): MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank.Annals of the Rheumatic Diseases, online first.DOWNLOAD

2017

• Ning Z, Lee Y, Joshi PK, Wilson JF, Pawitan Y,Shen X(2017): A selection operator for summary association statistics reveals allelic heterogeneity of complex traits.American Journal of Human Genetics, 101(6): 903-912; doi: 10.1016/j.ajhg.2017.09.027.DOWNLOAD

• Joshi PK, Pirastu N, Kentistou KA, Fischer K, Hofer E, Schraut KE, Clark DW, Nutile T, Barnes CLK, Timmers PRHJ,Shen X, Gandin I, McDaid AF, Hansen TF, Gordon SD, Giulianini F, Boutin TS, Abdellaoui A, Zhao W, Medina-Gomez C, Bartz TM, Trompet S, Lange LA, Raffield L, van der Spek A, Galesloot TE, Proitsi P, Yanek LR, Bielak LF, Payton A, Murgia F, Concas MP, Biino G, Tajuddin SM, Seppälä I, Amin N, Boerwinkle E, Børglum AD, Campbell A, Demerath EW, Demuth I, Faul JD, Ford I, Gialluisi A, Gögele M, Graff M, Hingorani A, Hottenga JJ, Hougaard DM, Hurme MA, Ikram MA, Jylhä M, Kuh D, Ligthart L, Lill CM, Lindenberger U, Lumley T, Mägi R, Marques-Vidal P, Medland SE, Milani L, Nagy R, Ollier WER, Peyser PA, Pramstaller PP, Ridker PM, Rivadeneira F, Ruggiero D, Saba Y, Schmidt R, Schmidt H, Slagboom PE, Smith BH, Smith JA, Sotoodehnia N, Steinhagen-Thiessen E, van Rooij FJA, Verbeek AL, Vermeulen SH, Vollenweider P, Wang Y, Werge T, Whitfield JB, Zonderman AB, Lehtimäki T, Evans MK, Pirastu M, Fuchsberger C, Bertram L, Pendleton N, Kardia SLR, Ciullo M, Becker DM, Wong A, Psaty BM, van Duijn CM, Wilson JG, Jukema JW, Kiemeney L, Uitterlinden AG, Franceschini N, North KE, Weir DR, Metspalu A, Boomsma DI, Hayward C, Chasman D, Martin NG, Sattar N, Campbell H, Esko T, Kutalik Z, Wilson JF (2017): Genome-wide meta-analysis associatesHLA-DQA1/DRB1andLPAand lifestyle factors with human longevity.Nature Communications, 8, 910; doi: 10.1038/s41467-017-00934-5.DOWNLOAD

• Shen X, Klarić L, Sharapov S, Mangino M, Ning Z, Wu D, Trbojević-Akmačić I, Pučić-Baković M, Rudan I, Polašek O, Hayward C, Spector TD, Wilson JF, Lauc G, Aulchenko YS (2017): Multivariate discovery and replication of five novel loci associated with Immunoglobulin GN-glycosylation.Nature Communications, 8, 447; doi: 10.1038/s41467-017-00453-3.DOWNLOAD

• Wang B, Li Z, Xu W, Feng X, Wan Q, Zan Y, Sheng S,Shen X(2017): Bivariate genomic analysis identifies a hidden locus associated with bacteria hypersensitive response in Arabidopsis thaliana.Scientific Reports, 7, 45281; doi: 10.1038/srep45281.DOWNLOAD

2016

• Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC,Shen X, Wilson JF, Chasman DI, Nolte IM, Tragante V, van der Laan SW, Perry JR, Kong A; BIOS Consortium, Ahluwalia TS, Albrecht E, Yerges-Armstrong L, Atzmon G, Auro K, Ayers K, Bakshi A, Ben-Avraham D, Berger K, Bergman A, Bertram L, Bielak LF, Bjornsdottir G, Bonder MJ, Broer L, Bui M, Barbieri C, Cavadino A, Chavarro JE, Turman C, Concas MP, Cordell HJ, Davies G, Eibich P, Eriksson N, Esko T, Eriksson J, Falahi F, Felix JF, Fontana MA, Franke L, Gandin I, Gaskins AJ, Gieger C, Gunderson EP, Guo X, Hayward C, He C, Hofer E, Huang H, Joshi PK, Kanoni S, Karlsson R, Kiechl S, Kifley A, Kluttig A, Kraft P, Lagou V, Lecoeur C, Lahti J, Li-Gao R, Lind PA, Liu T, Makalic E, Mamasoula C, Matteson L, Mbarek H, McArdle PF, McMahon G, Meddens SF, Mihailov E, Miller M, Missmer SA, Monnereau C, van der Most PJ, Myhre R, Nalls MA, Nutile T, Kalafati IP, Porcu E, Prokopenko I, Rajan KB, Rich-Edwards J, Rietveld CA, Robino A, Rose LM, Rueedi R, Ryan KA, Saba Y, Schmidt D, Smith JA, Stolk L, Streeten E, Tönjes A, Thorleifsson G, Ulivi S, Wedenoja J, Wellmann J, Willeit P, Yao J, Yengo L, Zhao JH, Zhao W, Zhernakova DV, Amin N, Andrews H, Balkau B, Barzilai N, Bergmann S, Biino G, Bisgaard H, Bønnelykke K, Boomsma DI, Buring JE, Campbell H, Cappellani S, Ciullo M, Cox SR, Cucca F, Toniolo D, Davey-Smith G, Deary IJ, Dedoussis G, Deloukas P, van Duijn CM, de Geus EJ, Eriksson JG, Evans DA, Faul JD, Sala CF, Froguel P, Gasparini P, Girotto G, Grabe HJ, Greiser KH, Groenen PJ, de Haan HG, Haerting J, Harris TB, Heath AC, Heikkilä K, Hofman A, Homuth G, Holliday EG, Hopper J, Hyppönen E, Jacobsson B, Jaddoe VW, Johannesson M, Jugessur A, Kähönen M, Kajantie E, Kardia SL, Keavney B, Kolcic I, Koponen P, Kovacs P, Kronenberg F, Kutalik Z, La Bianca M, Lachance G, Iacono WG, Lai S, Lehtimäki T, Liewald DC; LifeLines Cohort Study, Lindgren CM, Liu Y, Luben R, Lucht M, Luoto R, Magnus P, Magnusson PK, Martin NG, McGue M, McQuillan R, Medland SE, Meisinger C, Mellström D, Metspalu A, Traglia M, Milani L, Mitchell P, Montgomery GW, Mook-Kanamori D, de Mutsert R, Nohr EA, Ohlsson C, Olsen J, Ong KK, Paternoster L, Pattie A, Penninx BW, Perola M, Peyser PA, Pirastu M, Polasek O, Power C, Kaprio J, Raffel LJ, Räikkönen K, Raitakari O, Ridker PM, Ring SM, Roll K, Rudan I, Ruggiero D, Rujescu D, Salomaa V, Schlessinger D, Schmidt H, Schmidt R, Schupf N, Smit J, Sorice R, Spector TD, Starr JM, Stöckl D, Strauch K, Stumvoll M, Swertz MA, Thorsteinsdottir U, Thurik AR, Timpson NJ, Tung JY, Uitterlinden AG, Vaccargiu S, Viikari J, Vitart V, Völzke H, Vollenweider P, Vuckovic D, Waage J, Wagner GG, Wang JJ, Wareham NJ, Weir DR, Willemsen G, Willeit J, Wright AF, Zondervan KT, Stefansson K, Krueger RF, Lee JJ, Benjamin DJ, Cesarini D, Koellinger PD, den Hoed M, Snieder H, Mills MC (2016): Genome-wide analysis identifies 12 loci influencing human reproductive behavior.Nature Genetics, 48, 1462-1472.DOWNLOAD

• Weng Z, Wolc A,Shen X, Fernando RL, Dekkers JCM, Arango J, Settar P, Fulton JE, O’Sullivan NP and Garrick DJ (2016): Effects of number of training generations on genomic prediction for various traits in a layer chicken population.Genetics Selection Evolution, 48:22.DOWNLOAD

• Zan Y,Shen X, Forsberg S, and Carlborg O (2016): Genetic Regulation of Transcriptional Variation in Natural Arabidopsis thaliana Accessions.G3, 6(8):2319-2328.DOWNLOAD

• (Authors in alphabetical order) 79 other authors,Shen X, 21 other authors (2016): Crowdsourced estimation of cognitive decline and resilience in Alzheimer’s disease.Alzheimer’s & Dementia, 12(6): 645-53.DOWNLOAD

2015

• Lachowiec J,Shen X, Queitsch C and Carlborg O (2015): A genome-wide association analysis reveals epistatic cancellation of additive genetic variance for root length in Arabidopsis thaliana.PLoS Genetics, 11(9), e1005541.DOWNLOAD

• Shen Xand Zhan Y (2015): RE: The effect on melanoma risk of genes previously associated with telomere length.Journal of the National Cancer Institute, 107(10): djv237.DOWNLOAD

• Alam M and Ronnegard L andShen X(2015): Fitting conditional and simultaneous autoregressive spatial models in hglm.The R Journal, 7(2): 5-18.DOWNLOAD

• Besnier F, Glover K, Lien S, Kent M, Hansen M,Shen Xand Skaala O (2015). Identification of quantitative genetic components of fitness variation in farmed, hybrid and native salmon in the wild.Heredity, 115, 47-55.DOWNLOAD

2014

• Shen X, Forsberg S, Pettersson M, Sheng Z and Carlborg O (2014): Natural CMT2 variation is associated with genome-wide methylation changes and temperature seasonality.PLoS Genetics, 10(12), e1004842.DOWNLOAD

• Shen Xand Hill WG (2014): Opportunities for improvement of phenotypic variability: influence of direct vs epistatic effects.Proceedings of the 10th WCGALP.DOWNLOAD

• Ronnegard L, Felleki M, Alam M andShen X(2014): Simultaneous estimation of spatial and genetic effects using hierarchical generalized linear models.Proceedings of the 10th WCGALP.DOWNLOAD

• Shen X, Alam M and Ronnegard L (2014): Mixed models through the lens of hglm: applications and grand challenges.JSM Proceedings.DOWNLOAD

• Shen X, Li Y, Ronnegard L, Uden P and Carlborg O (2014): Application of a genomic model in chemometrics analysis.Journal of Chemometrics, 28: 548-557.DOWNLOAD