生平简介

2001于约翰·霍普金斯大学获得博士学位，师从Richard L. Huganir教授，主要从事神经突触转导、男性不育的病因学研究，以及学习与记忆的分子机制研究。

研究领域

Globozoospermia（圆头精子症，又名round-headed spermatozoa）是一种以精子顶体异常为主要特征的不育综合症，是一种罕见的不育疾病。夏军教授以及其香港科技大学的同事在一项新的研究中以雄性小鼠为研究模型，找出一种与不育有关的蛋白，PICK1，深入研究发现缺乏PICK1的雄性小鼠其临床上的表征与人类男性圆头精子症类似，这一结果可能对研究人类男性圆头精子症有借鉴意义。

在小鼠模型中，缺乏PICK1蛋白会导致精子计数低，并且有限的精子异型（圆头），导致精子的游动能力受到极大的破坏。对这些异常的精子进行深入研究发现，精子的顶体发生畸变，正常来说顶体中含有特殊的蛋白能帮助精子穿透卵子的外层达到受精的作用。研究发现PICK1与顶体细胞结构中的另外两种蛋白有密切的联系，分别是GOPC和CK2-alpha。

这些结果表明，PICK1蛋白是促进精子顶体发育的关键蛋白，缺失PICK1蛋白将导致精子受破坏，失去活动能力和受精能力。这一研究成果可能对男性不育的治疗有新的意义。

所获荣誉

2008年首届东南亚高等教育协会—史高柏年轻科学家奖

发表论文

1. Xu, J., Xiao, N.,Xia, J.(2010). Thrombospondin 1 Accelerates Synaptogenesis in Hippocampal Neurons through Neuroligin 1.Nat. Neurosci.13 (1): 22-4.

2. Xiao, N., Kam, C., Shen, C., Jin, W., Wang, J., Lee, K.M., Jiang, L., andXia, J.(2009). PICK1 deficiency causes male infertility in mice by disrupting acrosome formation.J. Clin. Invest.119(4): 802-812.

3. Cao, M., Xu, J., Shen, C., Kam, C., Huganir, R.L., andXia, J.(2007). PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors.J. Neurosci.27(47): 12945-12956.

4. Pan, L., Wu, H., Shen, C., Shi, Y., Jin, W.,Xia, J.,*and Zhang, M.* (2007). Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.EMBO J.26(21): 4576-87. * Co-corresponding authors.

5. Jin, W., Ge, W., Xu, J., Cao, M., Peng, L., Yung, W., Liao, D., Duan, S., Zhang, M., andXia, J.(2006). Lipid binding regulates PICK1’s synaptic targeting, AMPA receptor trafficking and synaptic plasticity.J. Neurosci.26(9): 2380-2390.

6. Steinberg, J.P., Takamiya, K., Shen, Y.,Xia, J.,Rubio, M.E., Yu, S., Jin, W., Thomas, G.M., Linden, D.J., and Huganir, R.L. (2006). Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1Eliminate Cerebellar long-term depression.Neuron49(6): 845-860.

7. Gardner, S.M., Takamiya, K.,Xia, J., Suh, J., Johnson, R., Yu, S., and Huganir, R.L. (2005). Calcium-Permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF.Neuron45(6): 903-915.

8. Long, J.F., Feng, W., Wang, R., Chan, L.N., Ip, F.C.,Xia, J., Ip, N.Y., and Zhang, M. (2005). Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem.Nat. Struct. Mol. Biol.12(8): 722-8.

9.Xia, J., Chung, H.J., Wihler, C., Huganir, R.L., and Linden, D.J. (2000). Cerebellar long-term depression requires PKC regulated interactions between GluR2/3 and PDZ domain-containing proteins.Neuron.28(2): 499-510.

10.Xia, J., Zhang, X., Staudinger, J., and Huganir, R.L. (1999). Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.Neuron. 22(1): 179-87.