个人简介

周红刚

男

南开大学药学院讲师

生物化学

分子生物学，结构生物学，药物筛选与设计

2010毕业于英国雷丁大学（UniversityofReading,UK）药学院药理系，获博士学位；研究的主要方向是与重点药靶子G蛋白偶联受体（GPCR）相关通路的分子药物设计与筛选，包括运用分子生物学方法获得高纯度可溶性GPCR抑制蛋白，尝试运用多种技术获得底物与蛋白的结合证据及其结合力的测定，比如PulldownAssay,ITC,BIACore,MALDI,NMR和CD等技术，再通过共结晶或者浸泡的方式获得复合物晶体，通过结构解析得到其结构和结合信息，为药物设计提供强有力的基础。同时参与超级细菌NDM-1和蓝藻FPR等多种蛋白的解析工作以及多种药物筛选备选库的组建工作。

代表性作品

1) Guo Y, Wang J, Niu G, Shui W, Sun Y, Zhou H, Zhang Y, Yang C, Lou Z, Rao Z.A structural view of the antibiotic degradation enzyme NDM-1 from a superbug.Protein Cell. 2011 May;2(5):384-94. Epub 2011 Jun 2.

2) G. Cheng, C. Krasel, H. G. Zhou, D. Chappell, and I. W. Hamley. Genetic Expression of an Amyloid Peptide Fragment and Analysis of Formylated Products. Organic Letters. 2011,13(10), pp2572-2575.

3) Cheng Chen, Yanxin Wang, Honggang Zhou, Zheng Yin and Zihe Rao. Crystal Structure of EV71 RNA-Dependent RNA Polymerase in Complex with Its Protein Primer VPg: Implication for an in trans mechanism of EV71 replication complex.

4) Ting Liu, Yingli Shuai，Honggang Zhou. Purification, crystallization and preliminary X-ray diffraction of fluorescence recovery protein (FRP) from Synechocystis PCC 6803. (2011). Acta Crystallographica Section F.

5) Lihong Zhou, Jiejin Li, Roger George, Sandrine Ruchaud, Hong-Gang Zhou, John E. Ladbury, William C. Earnshaw and Xuemei Yuan.(2009). Effects of Full-Length Borealin on the Composition and Protein?Protein Interaction Activity of a Binary Chromosomal Passenger Complex. Biochemistry 48(6): 1156-1161

6) Jian Ming Wang,Hong Gang Zhou and Jun Xian Ren. (2002). The Research Method for Distillation of Aloe Amylose. Food Research and Development. 23(3): 21-24. ISSN 1005-6521