个人简介

陈河如，男，博士，教授，博士/硕士生导师。

1989年6月毕业于中山大学化学系，获理学学士学位及优秀毕业生称号；1995年6月毕业于中国科学院上海有机化学研究所并获理学硕士学位；1999年5月赴香港大学化学系进行合作研究，任助理研究员；2002年11月毕业于香港科技大学化学系并获哲学（化学）博士学位，同年赴加拿大蒙特利尔临床研究院（Clinical Research Institute of Montreal，Canada）进行合作研究，任博士后研究员。2007年2月赴德国Wuppertal大学进行学术访问，2008年2月回国。1989.7-2008.2期间，曾断续在汕头大学工作，历任助教、讲师、副教授、汕头大学多学科研究中心顾问等职。2008.3至今，任暨南大学药学院药物化学教授, 博士生导师。多年来从事天然产物的结构修饰、药物合成、有机合成、多肽科学及生物有机化学等领域的研究工作。已经主持和参加多项项国家自然科学基金项目、广东省自然科学基金重点项目、广东省科技厅社会发展重点项目、广东省高等院校自然科学研究重点项目和多项其它基金，已在国际及国内重要刊物发表论文100余篇，获授权专利9项，申请国际PCT专利2项。

科研情况

近五年25篇代表性论文（打*者为通讯作者）：

1. Minfeng Chen, Xueping Lei, Changzheng Shi, Baojian Wu, Zhengqiu li, Bin Du, Weili Han, Jianyang Hu, Qiulin Nie, Zhenjian Zhuo, Weiqian Mai, Maohua Huang, Nan Ma, Nanhui Xu, Xinyi Zhang, Liangping Luo, Ande Ma, HongSheng Li, Qiang Yu,Heru Chen*, Dongmei Zhang*, Wencai Ye*. Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents.J Clin Invest.2017, doi:10.1172/JCI94258 (IF 12.78).

2. Laitao Zhang, Yifang Li, Sheng Yuan, Shijie Zhang, Huanhuan Zheng, Jie Liu, Pinghua Sun, Yijun Gu, Hiroshi Kurihara, Rongrong He*,Heru Chen*. Bioactivity Focus of a-Cyano-4-hydroxycinnamic acid (CHCA) Leads to Effective Multifunctional Aldose Reductase Inhibitors.Sci Report2016, 6, 24942, doi: 10.1038/srep24942 (IF 5.28).

3. Zhihua Wang, Sheng Yuan, Yanbing Li, Zhe Zhang, Wei Xiao, Dan Tang, Kaihe Ye, Zhijun Liu, Congcong Wang, Yixiong Zheng, Hong Nie*,Heru Chen*. Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compoundhr5Fa potential agent for the treatment of diabetic complications.Biochem Pharmacology2018, 150, 54-63, 2018.01.034 (IF 5.09).

4. Jie Liu, Chao Zhang, Huailin Wang, Lei Zhang, Jianrun Zhang, Zhenlei Jiang, Zhijun Liu,Heru Chen*. Design synthesis of 1,3-dioxyxanthone nitrates and the studies on the synergistic anticancer activities.Eur. J. Med. Chem.2018, 151, 158-172 (IF 4.59).

5. Jie Liu, Fan Zhou, Lei Zhang, Huailin Wang, Jianrun Zhang, Chao Zhang, Zhenlei Jiang, Yanbing Li, Zhijun Liu,Heru Chen*. DMXAA-pyranoxanthone hybrids enhance inhibition activities against human cancer cells with multi-target functions.Eur. J. Med. Chem.2018, 143, 1768-1778 (IF 4.59).

6. Jie Liu, Fan Zhou, Lei Zhang, Huailin Wang, Jianrun Zhang, Chao Zhang, Zhenlei Jiang, Yanbing Li, Zhijun Liu,Heru Chen*. DMXAA-pyranoxanthone hybrids enhance inhibition activities against human cancer cells with multi-target functions.Eur. J. Med. Chem.2018, 143, 1768-1778 (IF 4.59)

7. Jie Liu, Jianrun Zhang, Huailin Wang, Zhijun Liu, Chao Zhang, Zhenlei Jiang,Heru Chen*. Synthesis of xanthone derivatives and the studies on the inhibition against cancer cells growth and synergistic effects of them.Eur. J. Med. Chem.2017, 133, 50-61 (IF 4.59).

8. Fu-xiang Jiang, Qiao-zhen Liu, Dan Zhao, Cui-ting Luo, Cui-ping Guo, Wen-cai Ye, Cheng Luo,Heru Chen. A concise synthesis ofN-substituted fagomine derivatives and the systematic exploration of their a-glycosidase inhibition.Eur J Med Chem2014, 77, 211-222. （IF 3.9）

9. Jing Zheng, Lijuan Deng, Minfeng Chen, Xuzhi Xiao, Shengwei Xiao, Cuiping Guo, Gaokeng Xiao, Liangliang Bai, Wencai Ye, Dongmei Zhang*,Heru Chen*. Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity.Eur J Med Chem,2013, 65, 158-167 （IF 3.5）

10. Wang, R., Yang, J., Peng, L., Zhao, J., Mu, N., Huang, J., Lazarovici, P.,Chen, H.*, and Zheng, W.* Gardenamide A attenuated cell apoptosis induced by serum deprivation via ERK1/2 and PI3K/Akt signaling pathways.Neuroscience2015, 286, 242-250. (IF3.3)

11. Rikang Wang, Jiaqiang Zhao, Lei Zhang, Xinyi Zhang, Wenhua Zheng*, andHeru Chen*. Genipin Derivatives Protect RGC-5 from Sodium Nitroprusside-Induced Nitrosative Stress.Int. J. Mol. Sci.2016, 17(1), 117; doi: 10.3390/ijms 17010117 (IF 3.15).

12. Jiaqiang Zhao, Lizhi Peng , Rikang Wang , Lei Zhang, Xinyi Zhang, Jian Yang, Wenhua Zheng*,Heru Chen*. Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects Against Corticosterone-Induced Insults in PC12 Cells.Int. J. Mol. Sci.2015, (IF2.8)

13. Rikang Wang, Lizhi Peng, Jiaqiang Zhao, Laitao Zhang, Cuiping Guo, Wenhua Zheng*,Heru Chen*. Gardenamide A Protects RGC-5 Cells from H2O2-induced Oxidative Stress Insults by Activating PI3K/Akt/eNOS Signaling Pathway.Int. J. Mol. Sci.2015, (IF2.8)

14. Wang, R., Yang, J., Zhang, L., Xiao, G., Luo, J., Liao, S.,Chen, H.*, and Zheng W.* Stereoselective Reduction of 1-O-Isopropyloxygenipin Enhances Its Neuroprotective Activity against Apoptosis in PC12 Cells Induced by Sodium Nitroprusside.ChemMedChem2014, 9(7), 1397-1401. （IF 3.15）