科研情况

主要研究方向：

药物新剂型、药物吸收与代谢及药代动力学。

发表论文：（* 通讯作者）

1.WuB*,DongD.(2012)Humanglutathionetransferases:structure,function,and drug dis-covery.TrendsPharmacolSci.33(12):656-668.(IF:9.3)2.WuB*,LiS,DongD.(2013)3Dstructuresandligandspecificitiesofnuclearxenobiotic receptorsCAR,PXR,andVDR.DrugDiscovToday.18(11-12):574-81.(IF:6.6)3.WuB*(2011)Substrateinhibitionkineticsindrugmetabolismreactions.DrugMetab Rev.43(4):440-456.(IF:5.5)4.DongD,WuB*,ChowD,HuM(2012)Substrateselectivityofhumancytochrome p450spredi-cted fromcrystalstructuresandinsilicomodeling.DrugMetabRev.44(2):192-208.(IF:5.5)5.ZhouX,MaZ,DongD,WuB*,(2013)ArylamineN-acetyltransferases:AStructural Perspec-tive.BrJPharmacol.169(4):748-60.(IF:5.1)6.WuB,WangX,ZhangS,HuM(2012)Accuratepredictionofglucuronidationof structurally diversephenolicsbyhumanUGT1A9usingcombinedexperimentaland insilicoapproaches.Pharm Res.29(6):1544-1561.(IF:4.7)（封面论文）7.WuB,JiangW,YinT,GaoS,HuM(2012)Anewstrategytorapidlyevaluate kineticsof glucuronideeffluxbyBCRP/ABCG2.PharmRes.29(11):3199-3208.(IF:4.7)8.WuB,XuB,HuM(2011)Regioselectiveglucuronidationofflavonolsbysixhuman UGT1A isoforms.PharmRes.28(8):1905-1918.(IF:4.7)9.WuB,ZhangX,HuM(2011)Evaluationof3,3’,4’-trihydroxyflavoneand3,6,4’-trihydro-xyflavone(4’-O-glucuronidation)astheprobesubstratesforhepaticUGT1A1.MolPharm. 8(6): 2379-2389.(IF:4.6)10.WuB,BasuS,MengS,WangX,HuM(2011)Regioselectivesulfationand glucuronidation ofphenolics:insightsintothestructuralbasis.CurrDrugMetab.12(9):900-916.(IF: 4.4)11.WuB,MorrowJK,SinghR,ZhangS,HuM(2011)3D-QSARstudiesonUGT1A9-mediated3-O-glucuronidationofflavonolsusingapharmacophore-basedCOMFAmodel.JPharmacolExp Ther. 336(2):403-413.(IF:3.9)12.WuB*,DongD,HuM,ZhangS*(2013)Quantitativepredictionofglucuronidation in humans usingtheinvitro-invivoextrapolationapproach.CurrTopMedChem.13(11):1343-52.(IF:3.7)13.WuB,DengD,LuY,WuW(2008)Biphasicreleaseofindomethacinfrom HPMC/pectin/calcium matrixtablet:II.Influencingvariables,stabilityand pharmacokineticsindogs.EurJ Pharm Biopharm.69(1):294-302.(IF:3.8).14.WuB,ChenZ,WeiX,SunN,LuY,WuW(2007)Biphasicreleaseof indomethacinfrom HPMC/pectin/calciummatrixtablet:I.Characterizationand mechanisticstudy.EurJ Pharm Biopharm.67(3):707-714.(IF:3.8)15.MaZ,LiuH，WuB*(2013)Structure-baseddrugdesignofcatechol-O-methyltransferase inhibitorsforCNSdisorders.BrJClinPharmacoldoi:10. 1111/bcp.12169.(IF:3.6).16.WuB*(2011)PharmacokineticinterplayofphaseIImetabolismandtransport: atheoretical study.JPharmSci.101(1):381-393.(IF:3.1).17.WuB*(2012)Useofphysiologicallybasedpharmacokineticmodelstoevaluate theimpact ofintestinalhydrolysisofglucuronideonthepharmacokineticsof aglycone.JPharm Sci.101(3):1281-1301.(IF:3.1).18.WuB,KulkarniK,BasuS,ZhangS,HuM(2011)First-passmetabolismviaUDP-glucuronosyl transferase:abarriertooralbioavailabilityofphenolics.JPharmSci. 100(9):3655-3681. (IF:3.1).19.DongD,WuB*(2012)InsilicomodelingofUGT1A10substratesusingthe VolSurfapproach.JPharmSci.101(9):3531-3539.(IF:3.1).20.LiJ，MaZ，JiangR，WuB*（2013）Hormone-relatedpharmacokineticvariations associated withanti-breastcancerdrugs.ExpertOpinDrugMetabToxicol.9(9):1085-95.(IF:2.9).21.DongD,AkoR,WuB*(2012)Crystalstructuresofhumansulfotransferases: insightsinto themechanismsofactionandsubstrateselectivity.ExpertOpinDrug MetabToxicol.8(6):635-646.(IF:2.9).22.LuD,ZhangJ,YangZ,LiuH,LiS,WuB*,MaZ*(2013)Quantitativeanalysis of Cistan-ches HerbausingHPLC-DAD-HRMScombinedwithchemometricmethods.JSepSci.36(12):1945-52.(IF:2.6).23.LiuW,LiuH,SunH,DongD,MaZ,WangY,WuB*(2013)MetaboliteElucidation ofthe Hsp-90 InhibitorSNX-2112UsingUltraperformanceLiquidChromatography/QuadrupoleTime-of-flightMassSpectrometry(UPLC-QTOF/MS).Xenobiotica.(已接收)(IF:2.0)24.AkoR,DongD,WuB*(2012)3D-QSARstudiesonUDP-glucuronosyltransferase2B7 substrates usingthepharmacophoreandVolSurf approaches.Xenobiotica.42(9):891-900.(IF:2.0)25.LiuH,MaZ,WuB*.(2013)Structure-activityrelationshipsandinsilicomodelsofP-glycoprotein(ABCB1)inhibitors.Xenobiotica.43(11):1018-26.(IF:2.0)26.DongD,AkoR,HuM,WuB*(2012)UnderstandingSubstrateSelectivityof HumanUDP-glucur-onosyltransferasesthroughQSARmodelingandanalysisofthehomologous enzymes.Xenobiotica. 42(8):808-820.(IF:2.0)27.WuB,ShunN,WeiX,WuW(2007)Characterizationof5-fluorouracilreleasefrom hydroxy-propyl methylcellulosecompression-coatedtablets.PharmDevTechnol. 12(2):203-210.(IF:1.3).

科研项目

1.国家自然科学基金面上项目：植物糖基转移酶高表达工程菌减轻抗癌药伊立替康毒性研究 （81373496）， 起止时间：2014.1-2017.12。（75万元，主持）。2.广州市珠江科技新星人才计划（30万元，主持）。

发明专利

1.Methodsformakingandusingdrugdetoxifyingbacteria.（美国专利申请号:61/583,711）2.一种间苯三酚口腔崩解片及其制备方法。（专利号:200710172518.3）3.一种用于结肠定位给药的在体交联包芯片。（专利号:200610029476.3）

社会兼职

1.杂志编委JournalofPharmacologyResearch;JournalofSingleCellGenomics&Proteomics2.美国药学科学家协会（AAPS）会员3.美国药理学与实验治疗学会（ASPET）会员4.美国OMICSGroup会员5.SCI杂志审稿人MolecularPharmaceutics;BritishJournalofPharmacology;PLoSONE;Foodand Chemical Toxicology; Xenobiotica;JournalofPharmacyandPharmacology; InternationalJournal ofNanomedicine; CurrentPharmaceuticalAnalysis; Biopharmaceutics&DrugDisposition; üInternationalJournalofMolecularSciences; AnalyticalBiochemistry;CurrentMedicinal Chemistry;BioMedResearchInternational;Mini-ReviewsinMedicinalChemistry等